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BWillie · Yesterday, 10:23 PM

Any CP members take Lions Mane often and other Nootropics? Wondering if it is placebo or actually works. I have issues with anxiety. I do not really have issues with concentration. Usually the two go hand in hand but not for me. I've tried quite a few different drugs and nootropics to help me navigate through life. I'm pretty introverted but can be very conversational under the right circumstances. It's just exhausting sometimes faking extroversion and the anxiety that can come from it.

Nootriopics/Drugs I've tried
--PS128 Medical Probiotic - This has almost been life-changing on how it positively affects my mood and lowers my frustration level
--Marijuana - Unlike most this actually INCREASES my anxiety and can give me paranoia yet it quickly makes me tired and want to sleep.
--GABA - I suppose gives a heightened since of clarity for a very short time but just doesn't last then gives me a tingling annoying feeling on my skin
--Caffeine -- I intake around 600 mg daily and it really helps me with clarity, focus and just general alertness. I get cranky if I don't take it. It makes me LESS anxious.
--Ashwagandha -- does absolutely nothing
--Alpha GPC -- nothing I can notice
--L-Theanine -- This does work but it is mild. When taking it with caffeine it kind of counter acts it though
-- Adderal -- Makes me feel great and confident. I don't know about clarity though...Ill notice I think Im in perfect clarity but will make a bad decision. Also unhealthy.
--COQ10 -- Dont really know what it does
--Modafinil -- Pretty amazing but dont know long term effects as its a drug and difficult to get a prescription
--Alcohol -- completely alleviates anxiety but makes me dumb and silly. Also not healthy and too much will make me cranky when I get hungover and coming down.

Thinking about trying Lions Mane and 5-HTP

'Hamas' Jenkins · Today, 06:08 AM

I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.

Marcellus · Today, 08:58 AM

Quote:

Originally Posted by 'Hamas' Jenkins

I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.

Are you saying that drinking protein shakes doesn't do you any good as a dietary supplement or is that not part of the structure/function purpose you are talking about? I assume you are talking about the new craze of people taking peptides in oral form for things like improving HGH levels etc...?

'Hamas' Jenkins · Today, 09:15 AM

Quote:

Originally Posted by Marcellus

Are you saying that drinking protein shakes doesn't do you any good as a dietary supplement or is that not part of the structure/function purpose you are talking about? I assume you are talking about the new craze of people taking peptides in oral form for things like improving HGH levels etc...?

Structure/function meaning medicinal benefits, not nutrition. It's why supplements aren't regulated by the FDA. They can't make claims about structure or function. Protein shakes will give you protein. 5-HT is serotonin, but when taken orally, it undergoes confirmational changes as it is metabolized, which alters its affinity for its receptors. When you take it, you're paying a lot of money for very little amino acid.

Marcellus · Today, 09:18 AM

Quote:

Originally Posted by 'Hamas' Jenkins

Structure/function meaning medicinal benefits, not nutrition. It's why supplements aren't regulated by the FDA. They can't make claims about structure or function. Protein shakes will give you protein. 5-HT is serotonin, but when taken orally, it undergoes confirmational changes as it is metabolized, which alters its affinity for its receptors. When you take it, you're paying a lot of money for very little amino acid.

Ok that's what I thought you meant. I noticed a lot of companies are trying to sell oral peptides now but everything I have read says they have to be injected to be effective.

Oral serotonin not being effective is new info for me though.

In a nutshell what you are saying is any amino acid based compound isn't effective taken orally (if taken for functional purposes).

'Hamas' Jenkins · Today, 09:43 AM

Quote:

Originally Posted by Marcellus

Ok that's what I thought you meant. I noticed a lot of companies are trying to sell oral peptides now but everything I have read says they have to be injected to be effective.

Oral serotonin not being effective is new info for me though.

In a nutshell what you are saying is any amino acid based compound isn't effective taken orally (if taken for functional purposes).

In about 99.5% of the cases, yes. That's why treatments for depression work on serotonin reuptake by neurotransmitters. You can't ingest more serotonin, but if you prevent the neurotransmitters from hoovering back up, you allow the existing serotonin to exert its effects over a longer period which enhances mood.

Bioavailability is key.

**penguinz** · Today, 09:38 AM

Quote:

Originally Posted by 'Hamas' Jenkins

I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.

Not 100% true. BPC-157 has been proven to aid in treatment and prevention of ulcers and other digestive track issues when taken orally.

BWillie · Today, 09:42 AM

Quote:

Originally Posted by penguinz

Not 100% true. BPC-157 has been proven to aid in treatment and prevention of ulcers and other digestive track issues when taken orally.

Almost every doctor Ive ever talked to think Nootropics is a bunch of hogwash. I assume most of it is but after taking a medical probiotic and seeing how theanine can work there has to be some benefits.

**penguinz** · Today, 10:18 AM

Quote:

Originally Posted by BWillie

Almost every doctor Ive ever talked to think Nootropics is a bunch of hogwash. I assume most of it is but after taking a medical probiotic and seeing how theanine can work there has to be some benefits.

BPC-157 isn't a nootropic. I was just using it as an example of an AA that is gastric stable and can be taken effectively orally.

Probably helps that BPC-157 is made naturally in the gastric lining.

Wisconsin_Chief · Today, 01:29 PM

Quote:

Originally Posted by BWillie

Almost every doctor Ive ever talked to think Nootropics is a bunch of hogwash. I assume most of it is but after taking a medical probiotic and seeing how theanine can work there has to be some benefits.

They are definitely not hogwash, the long term safety was my biggest concern. I tinkered around about 7-8 years ago with bulk powder and making my own capsules, I absolutely noticed a huge difference. Adrafinil was my favorite, totally legal and your liver converts it to Modofinil. I was really into it for about a year, but then I changed to a Keto/Carnivore lifestyle and my brain fog basically vanished, so I have no need for it anymore.

They definitely helped me in my early days of sales, that’s for sure. If you have brain fog issues, they are absolutely worth exploring. Just don’t cheap out on what you buy, because you get what you pay for when it comes to this stuff.

BWillie · Today, 04:40 PM

Quote:

Originally Posted by Wisconsin_Chief

They are definitely not hogwash, the long term safety was my biggest concern. I tinkered around about 7-8 years ago with bulk powder and making my own capsules, I absolutely noticed a huge difference. Adrafinil was my favorite, totally legal and your liver converts it to Modofinil. I was really into it for about a year, but then I changed to a Keto/Carnivore lifestyle and my brain fog basically vanished, so I have no need for it anymore.

They definitely helped me in my early days of sales, that’s for sure. If you have brain fog issues, they are absolutely worth exploring. Just don’t cheap out on what you buy, because you get what you pay for when it comes to this stuff.

Where did you get the Adrafinil? I feel like taking that instead of chugging two Red Bulls a day would be more healthy.

Never thought about making your own capsules. I'm sure powder is much cheaper. Was it a big pain in the ass or pretty easy process?

'Hamas' Jenkins · Today, 09:44 AM

Quote:

Originally Posted by penguinz

Not 100% true. BPC-157 has been proven to aid in treatment and prevention of ulcers and other digestive track issues when taken orally.

Okay, cool. Show me the study.

**penguinz** · Today, 10:13 AM

Quote:

Originally Posted by 'Hamas' Jenkins

Okay, cool. Show me the study.

https://pubmed.ncbi.

.nih.gov/21548867/

**loochy** · Today, 12:57 PM

Quote:

Originally Posted by penguinz

https://pubmed.ncbi.

.nih.gov/21548867/

I hate that stupid ass emoji that ruins so many links.

Mods, can we change the code for that one?

'Hamas' Jenkins · Today, 04:13 PM

Quote:

Originally Posted by penguinz

https://pubmed.ncbi.

.nih.gov/21548867/

That was a study conducted in rats and made no reference to enteral dosing.

Yesterday, 10:23 PM	Topic Starter
BWillie El Gato Gordo Loco BWillie's Avatar Join Date: Apr 2006 Location: Earth	Lion's Mane Mushrooms and Nootropica Any CP members take Lions Mane often and other Nootropics? Wondering if it is placebo or actually works. I have issues with anxiety. I do not really have issues with concentration. Usually the two go hand in hand but not for me. I've tried quite a few different drugs and nootropics to help me navigate through life. I'm pretty introverted but can be very conversational under the right circumstances. It's just exhausting sometimes faking extroversion and the anxiety that can come from it. Nootriopics/Drugs I've tried --PS128 Medical Probiotic - This has almost been life-changing on how it positively affects my mood and lowers my frustration level --Marijuana - Unlike most this actually INCREASES my anxiety and can give me paranoia yet it quickly makes me tired and want to sleep. --GABA - I suppose gives a heightened since of clarity for a very short time but just doesn't last then gives me a tingling annoying feeling on my skin --Caffeine -- I intake around 600 mg daily and it really helps me with clarity, focus and just general alertness. I get cranky if I don't take it. It makes me LESS anxious. --Ashwagandha -- does absolutely nothing --Alpha GPC -- nothing I can notice --L-Theanine -- This does work but it is mild. When taking it with caffeine it kind of counter acts it though -- Adderal -- Makes me feel great and confident. I don't know about clarity though...Ill notice I think Im in perfect clarity but will make a bad decision. Also unhealthy. --COQ10 -- Dont really know what it does --Modafinil -- Pretty amazing but dont know long term effects as its a drug and difficult to get a prescription --Alcohol -- completely alleviates anxiety but makes me dumb and silly. Also not healthy and too much will make me cranky when I get hungover and coming down. Thinking about trying Lions Mane and 5-HTP Last edited by BWillie; Today at 10:09 AM..
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Today, 06:08 AM	#2
'Hamas' Jenkins Now you've pissed me off! 'Hamas' Jenkins's Avatar Join Date: Jan 2006	I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.
Posts: 74,847	3 1