Mass Effect 5
 

Seems like we'll be going forward with the franchise, even after the changes at the top of BioWare last week. Probably going to be years before it comes out, and no idea where the franchise is headed, but at least there's some semblance of hope....

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I'm here for this, too.

From that trailer, I can't quite pick out the era you're playing in.

Lot of first contact stuff, but then the end points to it being post-Shepherd...

I'd love to see them spin out a Shepherd-based cult whose religious tenets are based on the choices made by YOU as Shepherd in the first 3 games.

In all of the iterations of ME3 endings Shepard dies, except for 1 of them. I’m operating under the assumption that will be the canonical ending and this game takes place some time in the not too distant future from that. What that means for the fate of Shepard, I have no idea.

Mass Effect 4 as far as I'm concerned. If that really is Liara, it could still be way in the future since asari are long lived.