|
03-18-2020, 03:02 PM | #6391 | |
THE RED MENACE
Join Date: Aug 2000
Location: Texas
|
Quote:
|
|
Posts: 32,449
|
03-18-2020, 03:02 PM | #6392 | |
Like I woke up in Wonderland..
Join Date: Oct 2005
Location: KCMO
|
Quote:
Its been a while since I've taken a science class, wtf does this mean? |
|
Posts: 18,699
|
03-18-2020, 03:03 PM | #6393 | |
It was not a fair catch
Join Date: Aug 2012
Location: Correcting papers
|
Quote:
|
|
Posts: 38,156
|
1 0 |
03-18-2020, 03:04 PM | #6394 |
In Search of a Life
Join Date: Mar 2006
|
|
Posts: 22,289
|
03-18-2020, 03:05 PM | #6395 | |
Seize life. Be an ermine.
Join Date: Jul 2001
Location: My house
|
Quote:
That seems like a really good thing. |
|
Posts: 142,964
|
03-18-2020, 03:05 PM | #6396 |
MVP
Join Date: Feb 2013
Location: Studio City, CA
|
Here's the Elon Musk thread. Whatever you think of Musk you can bet that he associates with a lot more intelligent people than we do. Worth a read
|
Posts: 13,357
|
03-18-2020, 03:05 PM | #6397 | |
Now you've pissed me off!
Join Date: Jan 2006
|
Quote:
First, trials need to have predictive power, which requires a given sample size. Their trial needed 48 patients for a predictive power of 85% (not great, not terrible) that hydroxychloroquine would be 50% efficacious in reducing the viral load by a week. They only had 42 patients. That is an issue. Their numbers are far higher than that regarding efficacy, especially when adding azithromycin. The trial has major limitations--small sample size, didn't meet power, which could cause issues with the soundness of the data--> there's still a chance that even though their p-values are low, which is good, that the lack of patients means you're saying a difference exists when one actually doesn't). They are open about the trial's limitations. With that said, those presenting with lower respiratory symptoms would be more likely to be helped by azithromycin, as it has been the standard of care for community acquired pnuemonia for years (to the point where it now needs to be augmented with beta-lactams in many populations due to overprescribing). However, I'd also be curious to know the clinical significance of them testing negative on PCR of a nasopharyngeal swab versus a clinical cure. The groups aren't well matched (large age discrepancy between control and intervention group). The study has issues, but hydroxychloroquine and azithromycin are relatively safe drugs if you don't have certain rare disorders (G6PD deficiency or a prolonged QT interval). I'd be fine signing off on that order. |
|
Posts: 74,966
|
2 0 |
03-18-2020, 03:07 PM | #6398 | |
In Search of a Life
Join Date: Jul 2009
|
Quote:
The control group were all young pts to if im' reading it correntlcy. |
|
Posts: 82,625
|
03-18-2020, 03:07 PM | #6399 | |
SuperBowl or bust
Join Date: Dec 2008
Location: BF Iowa
|
Quote:
The country is trying to identify what’s working in other countries and replicate it. Right now, the best proven response seems to be trying to stop the spread as early as we can through isolation so we don’t have what happened in Italy and other places happen on our front steps. There are no perfect answers. |
|
Posts: 47,478
|
03-18-2020, 03:10 PM | #6400 | |
Mahomes: We Are All Witnesses
Join Date: Mar 2003
Location: Miami, FL
|
Quote:
If it comes to that in the US, it will be interesting to see how narrowly grocery stores and pharmacies are defined. Will places like Walmart, Target and Costco be allowed to remain open since they sell groceries and have pharmacies, or will only stand alone grocery stores/pharmacies such as Price Chopper, Hy-Vee, Kroger, Publix, CVS, Walgreens, etc. be allowed to remain open? |
|
Posts: 42,947
|
03-18-2020, 03:10 PM | #6401 |
It was not a fair catch
Join Date: Aug 2012
Location: Correcting papers
|
We are also expecting snow this week so that will keep more people home. |
Posts: 38,156
|
03-18-2020, 03:10 PM | #6402 | |
Now you've pissed me off!
Join Date: Jan 2006
|
Quote:
I've been able to keep working through treatment, although days 3-7 after chemo have been pretty shitty. My hair finally started falling out last week, so I had my girls and wife buzz my head with dog clippers (because they carve through a hell of a lot more hair than a beard and mustache trimmer). Funny thing is, my hair is now growing again, but it will probably all fall out after the next treatment. I still have to shave, but only once a week or so instead of daily. I should probably just shave a goatee in while I still have a beard so I can truly become a member of the inner circle. |
|
Posts: 74,966
|
14 0 |
03-18-2020, 03:10 PM | #6403 |
Diablo Negro
Join Date: Sep 2003
|
|
Posts: 71,926
|
03-18-2020, 03:13 PM | #6404 | |
Now you've pissed me off!
Join Date: Jan 2006
|
Quote:
|
|
Posts: 74,966
|
1 0 |
03-18-2020, 03:14 PM | #6405 |
future chiefs fans
Join Date: Jan 2004
Location: oakland california
|
|
Posts: 23,988
|
|
|